Continuous cardiovascular monitoring can play a key role in precision health. However, some fundamental cardiac biomarkers of interest, including stroke volume and cardiac output, require invasive measurements, e.g., arterial pressure waveforms (APW). As a non-invasive alternative, photoplethysmography (PPG) measurements are routinely collected in hospital settings. Unfortunately, the prediction of key cardiac biomarkers from PPG instead of APW remains an open challenge, further complicated by the scarcity of annotated PPG measurements. As a solution, we propose a hybrid approach that uses hemodynamic simulations and unlabeled clinical data to estimate cardiovascular biomarkers directly from PPG signals. Our hybrid model combines a conditional variational autoencoder trained on paired PPG-APW data with a conditional density estimator of cardiac biomarkers trained on labeled simulated APW segments. As a key result, our experiments demonstrate that the proposed approach can detect fluctuations of cardiac output and stroke volume and outperform a supervised baseline in monitoring temporal changes in these biomarkers.

Photoplethysmography (PPG) sensors have been widely used in consumer wearable devices to monitor heart rates (HR) and heart rate variability (HRV). Despite the prevalence, PPG signals can be contaminated by motion artifacts induced from daily activities. Existing approaches mainly use the amplitude information to perform PPG peak detection. However, these approaches cannot accurately identify peaks, since motion artifacts may bring random and significant amplitude variations. To improve the performance of PPG peak detection, the time information can be used. Specifically, heart rates exhibit temporal consistency that consecutive heartbeat intervals in a normal person can have limited variations. To leverage the temporal consistency, we propose the Temporal Attentive U-Net, i.e., TAU, to accurately detect peaks from PPG signals. In TAU, we design a time module that encodes temporal consistency in temporal embeddings. We integrate the amplitude information with temporal embeddings using the attention mechanism to estimate peak labels. Our experimental results show that TAU outperforms eleven baselines on heart rate estimation by more than 22.4%. Our TAU model achieves the best performance across various Signal-to-Noise Ratio (SNR) levels. Moreover, we achieve Pearson correlation coefficients higher than 0.9 (p < 0.01) on estimating HRV features from low-noise-level PPG signals.

Photoplethysmography (PPG) is a widely used non-invasive physiological sensing technique, suitable for various clinical applications. Such clinical applications are increasingly supported by machine learning methods, raising the question of the most appropriate input representation and model choice. Comprehensive comparisons, in particular across different input representations, are scarce. We address this gap in the research landscape by a comprehensive benchmarking study covering three kinds of input representations, interpretable features, image representations and raw waveforms, across prototypical regression and classification use cases: blood pressure and atrial fibrillation prediction. In both cases, the best results are achieved by deep neural networks operating on raw time series as input representations. Within this model class, best results are achieved by modern convolutional neural networks (CNNs). but depending on the task setup, shallow CNNs are often also very competitive. We envision that these results will be insightful for researchers to guide their choice on machine learning tasks for PPG data, even beyond the use cases presented in this work.

Photoplethysmography (PPG) signal comprises physiological information related to cardiorespiratory health. However, while recording, these PPG signals are easily corrupted by motion artifacts and body movements, leading to noise enriched, poor quality signals. Therefore ensuring high-quality signals is necessary to extract cardiorespiratory information accurately. Although there exists several rule-based and Machine-Learning (ML) - based approaches for PPG signal quality estimation, those algorithms' efficacy is questionable. Thus, this work proposes a lightweight CNN architecture for signal quality assessment employing a novel Quantum pattern recognition (QPR) technique. The proposed algorithm is validated on manually annotated data obtained from the University of Queensland database. A total of 28366, 5s signal segments are preprocessed and transformed into image files of 20 x 500 pixels. The image files are treated as an input to the 2D CNN architecture. The developed model classifies the PPG signal as `good' or `bad' with an accuracy of 98.3% with 99.3% sensitivity, 94.5% specificity and 98.9% F1-score. Finally, the performance of the proposed framework is validated against the noisy `Welltory app' collected PPG database. Even in a noisy environment, the proposed architecture proved its competence. Experimental analysis concludes that a slim architecture along with a novel Spatio-temporal pattern recognition technique improve the system's performance. Hence, the proposed approach can be useful to classify good and bad PPG signals for a resource-constrained wearable implementation.